BAtMMaN: Bone marrow AdipocyTes in the Multiple MyelomA Niche

Basic Information

Funding Cycle : 2024-2025

Name : Marta Diaz-delCastillo

Type of Award : Translational Research Award

Home Institution : University of Aarhus, Denmark

Description

Aging and obesity are the two main risk risk factors for multiple myeloma tumorigenesis, and both are characterized by an increase in bone adiposity, suggesting a crucial role for bone marrow adipocytes in cancer development. Previous research suggests that bone marrow adiposity influences plasma cell transformation, proliferation and resistance to therapy, and reciprocal interactions can reprogram the adipocytes´ transcriptome. In this project, we will apply advanced molecular histology and animal models to evaluate the role of resident bone marrow adipocytes on multiple myeloma development from premalignant conditions and investigate their potential as druggable candidates to prevent cancer development.

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