Characterizing the emergence of T cell dysfunction as a cause of therapy failure and disease progression in multiple myeloma
Basic Information
Funding Cycle :
2024-2025
Name :
Ross Firestone
Type of Award :
Career Development Award
Home Institution :
Memorial Sloan Kettering Cancer Center
Host Institution :
University of Miami
Description
Using comprehensive immune profiling techniques, I will investigate the role that immune dysfunction plays throughout the myeloma disease course. This includes immune profiling in patients with newly diagnosed multiple myeloma on immunomodulatory drugs as well as in relapsed or refractory multiple myeloma patients receiving bispecific antibodies. Through this immune profiling we hope to identify immune biomarkers predictive of clinical outcomes and identify novel treatment strategies to optimize patient immune function when receiving immune based therapies.
