Comprehensive Exploration of Molecular Pathways and Biomarkers in Myeloma-Induced Bone Disease: A Multi-Omics Approach for Personalized Therapeutic Management
Funding Cycle:
2024-2025Name:
Evangelos TerposType of Award:
Translational Research AwardHome Institution:
Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, GreeceDescription
The overarching objective of this proposal is to decipher the intricate molecular pathways, underlying myeloma-induced bone disease (MBD), a critical aspect of multiple myeloma pathogenesis. Employing state-of-the-art imaging, genomic and proteomic analyses, the proposal seeks to unravel the complex interplay between myeloma cells and the bone microenvironment. The objective of the proposal is to
- establish a robust panel of bone-specific biomarkers
- enhance the comprehensiveness of MBD strategies and
- to propose novel biomarker-based pharmacological modalities for MBD.
This integrated approach promises a deeper understanding of the spatial and functional aspects of bone lesions in multiple myeloma and a new insight on the pharmacological management of MBD.
