Deciphering the human plasma cell niche and its transformation in multiple myeloma by highly multiplexed tissue imaging
Basic Information
Funding Cycle :
2021-2022
Name :
Marc-Andrea Bärtsch
Type of Award :
Career Development Award
Home Institution :
Heidelberg University Hospital, Germany
Host Institution :
Stanford Univeristy
Description
This project aims to comprehensively analyze the spatial organization of the plasma cell niche and its alterations in monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) using CO-Detection by IndEXing (CODEX) multiplex tissue imaging. The study anticipates that cellular interactions within the bone marrow microenvironment generate specific tissue features, which can be identified and quantified using CODEX. These features will be correlated with clinical, genetic, and outcome data to understand their functional significance, potentially identifying prognostic markers and therapeutic targets for future investigation.
