Deciphering the human plasma cell niche and its transformation in multiple myeloma by highly multiplexed tissue imaging

Funding Cycle:

2021-2022

Name:

Marc-Andrea Bärtsch

Type of Award:

Career Development Award

Home Institution:

Heidelberg University Hospital, Germany

Host Institution:

Stanford Univeristy

Description

This project aims to comprehensively analyze the spatial organization of the plasma cell niche and its alterations in monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) using CO-Detection by IndEXing (CODEX) multiplex tissue imaging. The study anticipates that cellular interactions within the bone marrow microenvironment generate specific tissue features, which can be identified and quantified using CODEX. These features will be correlated with clinical, genetic, and outcome data to understand their functional significance, potentially identifying prognostic markers and therapeutic targets for future investigation.

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The International Myeloma Society is a professional, scientific, and medical society established to bring together clinical and experimental scientists involved in the study of myeloma. The purpose of this society is to promote research, education, clinical studies (including diagnosis and treatment), workshops, conferences, and symposia on all aspects of multiple myeloma worldwide.

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