DISCOVER NUTRIENTS – Understanding the relationship between nutrition and microbiome in MM

Basic Information

Funding Cycle : 2023-2024
Name : Lili Sophie Sester
Type of Award : Career Development Award
Home Institution : University of Heidelberg, Germany
Host Institution : University Hospital Tübingen, Germany

Description

This project aims to investigate the relationship between diet, microbiome composition, and response to standard-of-care treatment in newly diagnosed multiple myeloma (NDMM) patients. Stool samples from 150 NDMM patients will be analyzed alongside dietary data collected through interviews. These findings will be correlated with metabolome biomarkers using serum mass spectrometry. Patient-derived results will be validated in an immunocompetent MM in vivo model. The study seeks to develop a workflow for predicting response to anti-myeloma therapy. Additionally, preclinical interventions will explore how specific nutrients affect MM treatment response. Overall, this research aims to elucidate the mechanisms underlying diet-microbiome interactions in MM treatment response, potentially leading to personalized nutrition interventions for cancer patients.

Why Become a Member

The International Myeloma Society is a professional, scientific, and medical society established to bring together clinical and experimental scientists involved in the study of myeloma. The purpose of this society is to promote research, education, clinical studies (including diagnosis and treatment), workshops, conferences, and symposia on all aspects of multiple myeloma worldwide.

The IMS is a membership organization comprised of basic research scientists, and clinical investigators in the field along with physicians and other healthcare practitioners.

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