Discovering and targeting unprecedented mitochondrial vulnerabilities against multiple myeloma

Description

This research aims to target mitochondrial vulnerabilities in multiple myeloma (MM) by focusing on ClpP, a mitochondrial protease highly expressed in MM cells. Leveraging ClpP’s importance for MM cell survival, the study seeks to understand its function and identify novel mitochondrial vulnerabilities. Using functional geno-proteomics and genetic screening, the research aims to achieve two main objectives: 1) Understanding and targeting ClpP to devise new therapies, and 2) High-throughput screening to identify additional mitochondrial vulnerabilities in MM. Through these approaches, the study aims to uncover novel targets for more effective MM treatments, potentially leading to improved outcomes for patients with this incurable disease.