Dissecting and appraising novel mitochondrial vulnerabilities against multiple myeloma

Description

The study investigates mitochondria as crucial signaling hubs in cancer cells, particularly in multiple myeloma (MM), which may rely heavily on mitochondrial functions due to heightened stress experiences. The research focuses on the mitochondrial matrix protease ClpP, found to be essential for myeloma cell survival. Initial findings revealed ClpP’s role in regulating housekeeping autophagy and activating type I interferon responses, suggesting both cell-intrinsic and non-cell autonomous vulnerabilities. The project aims to dissect ClpP’s functions, resolve its structure in complex with inhibitors, and identify new mitochondrial vulnerabilities against MM using a multi-omic approach. Leveraging expertise in molecular biology, biochemistry, and genetic screening, the study seeks to uncover novel therapeutic targets for MM treatment, providing valuable insights into mitochondrial biology in cancer.