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Immunogenomics-guided adaptive cellular therapies in Multiple Myeloma
Funding Cycle:
2021-2022Name:
Paola NeriType of Award:
Translational Research AwardHome Institution:
University of Calgary, Cumming School of Medicine, Calgary, CanadaDescription
This proposal aimed to interrogate at single cell level the tumor microenvironment of CAR-T and TCE treated MM patients to elucidate the immune-mediated causes of resistance, identify potential means to reverse tolerance, and study how genomics might predict which patients should benefit the most from T-cell based therapies.