Investigating heme-induced effector CAR T cells for multiple myeloma therapy

Funding Cycle:

2024-2025

Name:

Mala Shanmugam

Type of Award:

Translational Research Award

Home Institution:

Winship Cancer Institute, Hematology Medical Oncology, Emory University School of Medicine

Description

Mitochondrial energetics and cellular metabolism play a central role in regulating T cell differentiation, fate and function. Heme (iron-protoporphyrin IX) is critical for maintaining mitochondrial electron transport chain (ETC) activity and oxidative phosphorylation (OXPHOS). Heme is taken up from the extrinsic environment in addition to being synthesized intracellularly. Our objective is to understand how heme regulates T cell exhaustion and the implications of extrinsic heme on BCMA-directed CAR-T cell therapy

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The International Myeloma Society is a professional, scientific, and medical society established to bring together clinical and experimental scientists involved in the study of myeloma. The purpose of this society is to promote research, education, clinical studies (including diagnosis and treatment), workshops, conferences, and symposia on all aspects of multiple myeloma worldwide.

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