Spatial and temporal tumor genomic heterogeneity in extramedullary multiple myeloma and solitary plasmacytoma with minimal marrow involvement
Basic Information
Funding Cycle :
2021-2022
Name :
Urvi Shah
Type of Award :
Career Development Award
Home Institution :
Memorial Sloan Kettering Cancer Center, New York, NY
Host Institution :
University of Miami/Sylvester Cancer Center
Description
To test the hypothesis that plasmacytomas can represent spatial and temporal clonal escape events, featuring distinct myeloma-defining genomic events characteristic of active disease, through the following specific aims:
Aim 1. Compare genomic driver events in paired samples from patients with newly diagnosed solitary plasmacytoma (SP) with minimal marrow involvement versus newly diagnosed multiple myeloma (NDMM) to identify myeloma-defining events in the plasmacytoma.
Aim 2. Compare genomic events in paired samples at MM relapse versus NDMM to identify genomic events associated extramedullary localization and progression of the disease.
