Spatial and temporal tumor genomic heterogeneity in extramedullary multiple myeloma and solitary plasmacytoma with minimal marrow involvement
Funding Cycle:
2021-2022Name:
Urvi ShahType of Award:
Career Development AwardHome Institution:
Memorial Sloan Kettering Cancer Center, New York, NYHost Institution:
University of Miami/Sylvester Cancer CenterDescription
To test the hypothesis that plasmacytomas can represent spatial and temporal clonal escape events, featuring distinct myeloma-defining genomic events characteristic of active disease, through the following specific aims:
Aim 1. Compare genomic driver events in paired samples from patients with newly diagnosed solitary plasmacytoma (SP) with minimal marrow involvement versus newly diagnosed multiple myeloma (NDMM) to identify myeloma-defining events in the plasmacytoma.
Aim 2. Compare genomic events in paired samples at MM relapse versus NDMM to identify genomic events associated extramedullary localization and progression of the disease.
