Systematic functional genomics characterization of 17p13(del) multiple myeloma

Funding Cycle:

2021-2022

Name:

Teoh Phaik Ju

Type of Award:

Career Development Award

Home Institution:

University of Singapore, Singapore

Host Institution:

Dana-Farber Cancer Institute

Description

This project aims to systematically characterize the functional genomics of 17p13 deletion in multiple myeloma (MM). Aim 1 seeks to identify potential tumor suppressor genes (TSGs) within 17p13 that cooperate with TP53 loss, investigating if haploinsufficiency of these genes contributes to MM pathogenesis. Aim 2 aims to define therapeutic vulnerabilities in MM cells with 17p loss, hypothesizing that TP53 loss confers pronounced dependence on certain genes or new vulnerabilities. This will be explored through the concept of synthetic lethality with TP53 loss, utilizing dual CRISPR knockout approaches. These aims aim to uncover critical insights into the biology of 17p13 deletion MM and potentially identify new targeted therapies for this high-risk subtype.

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The International Myeloma Society is a professional, scientific, and medical society established to bring together clinical and experimental scientists involved in the study of myeloma. The purpose of this society is to promote research, education, clinical studies (including diagnosis and treatment), workshops, conferences, and symposia on all aspects of multiple myeloma worldwide.

The IMS is a membership organization comprised of basic research scientists, and clinical investigators in the field along with physicians and other healthcare practitioners.

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