Systematic functional genomics characterization of 17p13(del) multiple myeloma

Basic Information

Funding Cycle : 2021-2022
Name : Teoh Phaik Ju
Type of Award : Career Development Award
Home Institution : University of Singapore, Singapore
Host Institution : Dana-Farber Cancer Institute

Description

This project aims to systematically characterize the functional genomics of 17p13 deletion in multiple myeloma (MM). Aim 1 seeks to identify potential tumor suppressor genes (TSGs) within 17p13 that cooperate with TP53 loss, investigating if haploinsufficiency of these genes contributes to MM pathogenesis. Aim 2 aims to define therapeutic vulnerabilities in MM cells with 17p loss, hypothesizing that TP53 loss confers pronounced dependence on certain genes or new vulnerabilities. This will be explored through the concept of synthetic lethality with TP53 loss, utilizing dual CRISPR knockout approaches. These aims aim to uncover critical insights into the biology of 17p13 deletion MM and potentially identify new targeted therapies for this high-risk subtype.

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