In over half of multiple myeloma patients, RAS mutation is prevalent, presenting a currently undruggable target. Previous research conducted by the Lentzsch Lab revealed an upregulation of germinal center kinase (GCK) associated with RAS mutations, offering a new therapeutic approach (Li et al., Blood, 2021). Inhibition of GCK, achieved through either knockout or drug intervention, … Continued
The research plan aims to assess the utility of mass spectrometry (MS) for diagnosing and monitoring patients with multiple myeloma (MM), amyloidosis (AL), and Waldenström’s macroglobulinemia (WM). Specific aims include comparing MS with standard methods like serum protein electrophoresis (SPEP) and immunofixation (IFE) for identifying and quantifying monoclonal proteins, evaluating MS’s ability to detect minimal … Continued
The International Myeloma Society is a professional, scientific, and medical society established to bring together clinical and experimental scientists involved in the study of myeloma. The purpose of this society is to promote research, education, clinical studies (including diagnosis and treatment), workshops, conferences, and symposia on all aspects of multiple myeloma worldwide.
The IMS is a membership organization comprised of basic research scientists, and clinical investigators in the field along with physicians and other healthcare practitioners.
