The permissive immune microenvironment is a critical regulator of disease progression from SMM to overt MM, and defining these alterations is critical for the development of translational prognostic and mechanistic models of disease progression
Novel genomic approaches may enable better prediction of progression risk to multiple myeloma (MM) from the more indolent precursor stages of monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). In support of this, the Ghobrial and Getz laboratories have previously collected, analyzed, and published biomarkers from the tumor cell fraction of SMM … Continued